When it comes to the NFL playoff picture, perhaps no other game on the Week 16 NFL schedule is important as Cowboys vs. Eagles. Both teams sit at 7-7, and a win for Dallas clinches the NFC East and the No. 4 seed in the NFC playoff bracket, while the loser will likely miss the playoffs altogether. The latest Week 16 NFL odds give the Cowboys a 2.5-point edge on the road in that crucial matchup.

Is that one of the Week 16 NFL spreads you should be all over, or do other pivotal matchups like Saints vs. Titans (+3) or Ravens vs. Browns (+10) provide more value? Before finalizing any NFL picks, be sure to see the NFL predictions from the team at SportsLine. All of the Week 16 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 16 NFL picks now.

Winning picks from a proven model

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on its top-rated NFL picks since its inception four years ago. It’s on a 95-65 roll on top-rated picks that dates back to 2017, and last season, the model also ranked in the Top 10 on NFLPickWatch for the third year in a row on straight-up NFL picks and beat more than 96 percent of CBS Sports office pool players.

Anyone who has followed it has consistently beaten NFL odds and is way up. Now, the computer examined the latest Week 16 NFL odds and lines, simulated every snap, and its Week 16 NFL predictions are in

Week 16 NFL picks to target

One of the model’s strongest Week 16 NFL predictions is that the Saints (-3) cover the spread against the Titans. New Orleans played perhaps its most complete game of the season in a 34-7 dismantling of Indianapolis in Week 15. Tennessee (8-6), meanwhile, had its four-game winning and covering streak broken in a 24-21 loss to the Texans last week.

The Saints (11-3) are 9-5 against the spread overall and a sizzling 5-1 against the number on the road. Drew Brees, Michael Thomas and company could have a field day against a Titans secondary that is without corner Malcolm Butler (wrist) and could also be missing corner Adoree Jackson (knee). SportsLine’s model is calling for almost 300 yards and two touchdowns from Brees as New Orleans covers in well over 50 percent of simulations, while the under (50.5) cashes more than 60 percent of the time. 

The model also has made the call against the spread, on the over-under, and on the money line for every other game on the Week 16 NFL schedule. It’s also projecting a Super Bowl contender to go down hard, so you need to see its NFL picks before locking in any of your own. Get every pick for every game here

Week 16 NFL odds

Who should you back against the spread, on the money line and the total in every Week 16 NFL game? And which Super Bowl contender goes down hard? Check out the latest NFL odds above, then visit SportsLine to see their Week 16 NFL cheat sheet, all from the model that is up over $7,000 on its top-rated NFL picks.