Robert Whittaker and Israel Adesanya are ready to throw down and figure out who is truly the best middleweight in the world as they face off in the main event of UFC 243 on Saturday night from Melbourne, Australia. The card is light on impactful fights between ranked opponents, but the main event is as legit as it comes, and there’s sure to be some big finishes throughout the evening.

Adesanya will be looking to secure his first full world title in UFC in just his seventh fight with the organization (and seventh fight since 2018). He has looked the part of superstar kickboxer, putting on a sick display in wins over Derek Brunson and Brad Tavares. Plus, winning a potential fight of the year over Kelvin Gastelum to secure the interim middleweight crown in April.

On the flip side, Whittaker has dealt with knee injuries, staph infection, an abdominal hernia and a twisted and collapsed bowel over the past few years, leading to a sharp dip in his activity. Whittaker has, however, become a legitimate international-level amateur wrestler while maintaining his UFC career and dealing with physical setbacks. 

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Below is all the information you need to catch the UFC 243 event on Saturday night. 

How to watch UFC 243 prelims

Date: Saturday, Oct. 5 | Location: Marvel Stadium — Melbourne, Australia
Time: 8 p.m. ET
Stream: Watch ESPN | Channel: ESPN 2

How to watch UFC 243 main card

Date: Saturday, Oct. 5 | Location: Marvel Stadium — Melbourne, Australia
Time: 10 p.m. ET
Stream: ESPN+ | Price: $59.99

Now, here’s a look at the UFC 243 main fight card and betting odds via MGM.

UFC 243 main card, odds

Favorite Underdog Weightclass

Israel Adesanya -120

Robert Whittaker (c) -110

Middleweight title

Dan Hooker -140

Al Iaquinta +110

Lightweight

Tua Tuivasa -370

Sergey Spivak +300

Heavyweight

Dhiego Lima -140

Luke Jumeau +110

Welterweight

Justin Tafa -125

Yorgan De Castro -105

Heavyweight

Who wins Adesanya vs. Whittaker, and how exactly does each fight end? Visit SportsLine now to get detailed picks on every fight at UFC 243, all from the incomparable expert who’s up nearly $21,000 on MMA in the past year, and find out.